nidhogge
03-25-2009, 01:23 PM
Hey guys! I'm a member of a couple hair loss forums on the net, and have researched and put together a topical independently over the last half a year that has a base primarily in well-researched, all-natural ingredients. Hair loss forums have given me hope between Laser Light Therapy and some phenomenal supplements, so I'm hoping that I can do my part to contribute as well by coming up with a hair loss formula that reduces hair loss down to non-MPB levels.
I apologize in advance to any moderators if this violates your terms in any way. I don't mean to come off as pitching a product, but I'm just trying to help Primordial get the adequate number of volunteers needed for this trial. I understand if you wish to remove the post. :)
Begins May 11, 2009
All of the ingredients have been sourced, and now it's time to gather the volunteer base. The price to participate in this trial is $30 + S&H. It is a paid trial to help offset the cost of the product, organization of data, and to help ensure dedication from the participants.
If you're interested in being a part of the trial, there will be approximately 180 spots.
To enter the trial, please make sure that you meet the following requirements –
Abstain from introducing/discontinuing any hair loss drugs or topical treatments from now, until the end of the Hairgen Trial. (Approx. for the next 6 months)
Submission of the requisition form
Submission of a close up picture(s) of the scalp Submit information to – hairgen@primordialperformance.com
Once approved for the trial, you will be provided with a link to purchase the Hairgen testing kit.
--------------------------------------------------
Requisition Form
First Name –
Last Name -
Age -
1. Are you currently taking any prescription hair loss drugs?
1a) If so, what drugs and how long have you been using these drug(s)?
1b) Do you plan on continuing to use these drugs for the next 6 months?
2. Are you currently using any topical hair loss products?
2a) If so, what products and how long have you been using these products?
2b) Do you plan on continuing to use these products for the next 6 months?
3. Do you have other known health issues or allergies? (heart, thyroid, adrenal, endocrine issues, etc.)
4. What Norwood level of hairloss are you currently experiencing? If unsure, please refer to the following site for information on Norwood scales: Hair Loss - Norwood Scale - How bald am I? (http://hairloss.cyberatlantis.com/library/norwood_scale.php)
5. Are you going to be making changes to your diet or exercise program in the next 6 months?
5a) If so, please explain in detail these changes.
6. Do you have someone that can take close-up pictures of your scalp during the next 6 months?
--------------------------------------------------
The Goal of HairGen
The goal of HairGen is to reduce hair loss to non-MPB levels, while also creating a healthy scalp environment that may potentially promote thicker hair and/or regrowth.
The herbs used in HairGen are all wild-harvested, which, while more costly, ensures that each ingredient is of the very finest quality. All of the herbs are distilled into liquid extracts via pure grape ethanol, therefore, the formulation will be roughly 40-60% organic grape alcohol. Ethoxydiglycol/PS-20 will be used to help bypass the lipid layer of the scalp to ensure proper penetration to the hair follicle.
Ingredients
Aloe Vera
Aloe Vera is an herb that can be beneficial for some forms of hair loss, and has been known to stimulate new growth. It is particularly beneficial to those that produce excessive amounts of scalp sebum. Further information on the benefits of topical Aloe Vera can be viewed at the following links:
Aloe Vera for Hair Loss (http://www.aloesajten.com/aloe-vera-for-hair-loss.php)
Another Reason to Love Aloe Vera, Hair Loss « StyleBell Blog - Your Premier Hair Resource (http://stylebell.wordpress.com/2008/04/18/another-reason-to-love-aloe-vera-hair-loss/)
Pueraria Mirifica
Pueraria Mirifica (PM) is an herb grown in Northern Thailand that has been traditionally used by Thais as a "fountain of youth," both internally and externally. Topical estrogen has been shown to be effective for treating MPB in both men and women, albeit with side-effects:
Topical estrogen for the treatment of pattern baldness (http://www.androgeneticalopecia.com/hair-loss-treatments/topical-estrogen-pattern-baldness.shtml)
Topical PM, on the other hand, acts as an estrogen mimicker due to its high miroestrol content, minus the side-effects caused by topical estrogen. Dr. Sandford Schwartz has researched PM for years, and his research, combined with the centuries of native Thai usage, has corroborated this claim. In fact, Dr. Sandford Schwartz has has sold his liquid PM extract formula to a well-known company in America to be distributed here for the purpose of hair regrowth. The formula consists exclusively of his liquid PM extract, by the name of Puresterol. Biobotanica is an independent U.S. distributor for Puresterol, and is our source of PM as well. You can read more about Puresterol at the following link:
Pueraria mirifica,Pueraria mirifica standardized extract, called Puresterol,research and studies,Puerariamirifica,pueraria, (http://www.puresterol.com)
Your trial bottle will either contain 0%, 2.5%, or 5% Pueraria Mirifica throughout the duration of this trial. We are not sure if PM will neutralize the other ingredients, if it will enhance it, or if it will make no discernible difference. The idea behind the variable amount is to test the optimal quantity for HairGen.
Adenosine
Adenosine is well-known around internet forums as a chemical that can increase the expression of Vascular Endothelial Growth Factor (VEGF), which has been found to be effective at thickening/terminalizing thin and vellous hairs. The amount of Adenosine in the formulation will be 3%. To view a study on the effectiveness of Adenosine, check out the following link:
Adenosine stimulates hair growth (http://news.hairlosshelp.com/hair-loss-studies/adenosine-stimulates-hair-growth/)
Sanguisorba Officinalis Extract
Sanguisorba Officinalis has an interesting method of action on the scalp that works in favor of preventing hair loss. Rather than reduce DHT, it inhibits Fibroblast Growth Factor-5 (FGF-5). FGF-5 is responsible for converting hairs from the Anagen (Growing) phase to the Telogen (Falling out) phase. By successfully inhibiting FGF-5, you can theoretically stop hair loss altogether. This, of course, does not apply to hairs currently in telogen phase prior to HairGen usage. You can view more information at the following link:
Science Links Japan | Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period (http://sciencelinks.jp/j-east/article/200704/000020070407A0130088.php)
Loquat Leaf Extract (Eriobotrya japonica)
The active component in Loquat Leaf Extract that yields promising results for hair loss is primarily Corosilic Acid. Corosilic Acid works in a similar manner to Sanguisorba Officinalis in that it regulates various growth factors when applied topically to the scalp. FGF-5 is downregulated (this works synergistically with Sanguisorba), while VEGF, FGF-7, and BMP-2, all of which are beneficial growth factors for hair loss, are upregulated. The following study offers further detailed information on the benefits of Loquat Leaf Extract and Corosilic Acid for hair loss:
Utilising loquat leaf extract for hair growth stimulation - Personal Care Magazine (http://www.personalcaremagazine.com/Story.aspx?Story=1911)
Semen Coicis Extract (Coix Seed or Coicis Lachryma-Jobi)
Though not as well-documented as some of the other ingredients in the formula, Coicis Semen has shown promise in the hair loss field as a Type II 5alpha-reductase inhibitor. The following study contains Coicis Semen as one of the primary ingredients in a hairloss formulation:
KMbase (http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0363620040250010152)
The next study refers to Thujae occidentalis semen, which is identical in action to Coicis Semen for our intents and purposes:
The extract of Thujae occidentalis semen inhibited...[J Dermatol Sci. 2003] - PubMed Result (http://www.ncbi.nlm.nih.gov/pubmed/12670719?dopt=AbstractPlus)
Swertia Chirata Extract
Swertia is effective as both an anti-inflammatory, and vasodilator. Topical application of Swertia can reduce shedding, while also encouraging thicker hair growth. Numerous hair loss formula patents have incorporated Swertia Chirata as a primary ingredient due to its Ayurvedic roots in hair loss treatment.
Red Panax Ginseng Extract
Red Panax Ginseng increases bloodflow and can stimulate hair follicles to encourage new hair growth. It has traditionally been used in Chinese medicine with success for thousands of years as a component in hair loss treatment. The following link has a large body of literature on uses for Red Panax Ginseng:
Panax ginseng C. A. Mey. (http://www.herbmed.org/Herbs/Herb108.htm)
Sophora Flavescens Extract
Hair loss studies point towards Sophora Flavescens as not only a potent inhibitor of Type II 5alpha-reductase, but also as an important regulator of growth factors.
The following study found that Insulin Growth Factor-1 (IGF-1) and Keratinocyte Growth Factor (KGF), both growth factors integral for hair growth, were up-regulated:
The hair growth promoting effect of Sophora flaves...[J Dermatol Sci. 2002] - PubMed Result (http://www.ncbi.nlm.nih.gov/pubmed/12354419?dopt=Abstract)
Toco-8
Toco-8 consists of the proper ratio of mixed Vitamin E tocotrienols that our bodies can make the best usage of. In a small study conducted by Primordial Performance, it was found that Toco-8 consumed internally can help in the fight against hair loss. Externally, it may be of even further benefit. Below is a link to a few live radio interviews with Primordial Performance President Eric Potratz regarding Toco-8 and the patented hair loss study:
http://www.primordialperformance.com/vbulletin/primordial-health/377-toco-8-balanced-tocotrienol-tocopherol-vitamin-e-supplement-radio-interview.html
Niacinamide
Topical Niacinamide has been shown to improve the condition of aged skin, helping to restore youthfulness and vitality. This may translate over to a healthier scalp that can improve the probability of thicker hair and potential regrowth. The following study demonstrates the effects of topical Niacinamide when applied to the face:
Wiley InterScience :: Session Cookies (http://www3.interscience.wiley.com/journal/118769826/abstract?CRETRY=1&SRETRY=0)
Niacin also acts as a vasodilator, which is similar in action to Minoxidil (sans the side-effects). A description of Niacin's vasodilation effects can be found here:
The role of niacin in detoxification (http://www.healingdaily.com/detoxification-diet/niacin.htm)
If you have any further questions, feel free to post them in this thread!
I apologize in advance to any moderators if this violates your terms in any way. I don't mean to come off as pitching a product, but I'm just trying to help Primordial get the adequate number of volunteers needed for this trial. I understand if you wish to remove the post. :)
Begins May 11, 2009
All of the ingredients have been sourced, and now it's time to gather the volunteer base. The price to participate in this trial is $30 + S&H. It is a paid trial to help offset the cost of the product, organization of data, and to help ensure dedication from the participants.
If you're interested in being a part of the trial, there will be approximately 180 spots.
To enter the trial, please make sure that you meet the following requirements –
Abstain from introducing/discontinuing any hair loss drugs or topical treatments from now, until the end of the Hairgen Trial. (Approx. for the next 6 months)
Submission of the requisition form
Submission of a close up picture(s) of the scalp Submit information to – hairgen@primordialperformance.com
Once approved for the trial, you will be provided with a link to purchase the Hairgen testing kit.
--------------------------------------------------
Requisition Form
First Name –
Last Name -
Age -
1. Are you currently taking any prescription hair loss drugs?
1a) If so, what drugs and how long have you been using these drug(s)?
1b) Do you plan on continuing to use these drugs for the next 6 months?
2. Are you currently using any topical hair loss products?
2a) If so, what products and how long have you been using these products?
2b) Do you plan on continuing to use these products for the next 6 months?
3. Do you have other known health issues or allergies? (heart, thyroid, adrenal, endocrine issues, etc.)
4. What Norwood level of hairloss are you currently experiencing? If unsure, please refer to the following site for information on Norwood scales: Hair Loss - Norwood Scale - How bald am I? (http://hairloss.cyberatlantis.com/library/norwood_scale.php)
5. Are you going to be making changes to your diet or exercise program in the next 6 months?
5a) If so, please explain in detail these changes.
6. Do you have someone that can take close-up pictures of your scalp during the next 6 months?
--------------------------------------------------
The Goal of HairGen
The goal of HairGen is to reduce hair loss to non-MPB levels, while also creating a healthy scalp environment that may potentially promote thicker hair and/or regrowth.
The herbs used in HairGen are all wild-harvested, which, while more costly, ensures that each ingredient is of the very finest quality. All of the herbs are distilled into liquid extracts via pure grape ethanol, therefore, the formulation will be roughly 40-60% organic grape alcohol. Ethoxydiglycol/PS-20 will be used to help bypass the lipid layer of the scalp to ensure proper penetration to the hair follicle.
Ingredients
Aloe Vera
Aloe Vera is an herb that can be beneficial for some forms of hair loss, and has been known to stimulate new growth. It is particularly beneficial to those that produce excessive amounts of scalp sebum. Further information on the benefits of topical Aloe Vera can be viewed at the following links:
Aloe Vera for Hair Loss (http://www.aloesajten.com/aloe-vera-for-hair-loss.php)
Another Reason to Love Aloe Vera, Hair Loss « StyleBell Blog - Your Premier Hair Resource (http://stylebell.wordpress.com/2008/04/18/another-reason-to-love-aloe-vera-hair-loss/)
Pueraria Mirifica
Pueraria Mirifica (PM) is an herb grown in Northern Thailand that has been traditionally used by Thais as a "fountain of youth," both internally and externally. Topical estrogen has been shown to be effective for treating MPB in both men and women, albeit with side-effects:
Topical estrogen for the treatment of pattern baldness (http://www.androgeneticalopecia.com/hair-loss-treatments/topical-estrogen-pattern-baldness.shtml)
Topical PM, on the other hand, acts as an estrogen mimicker due to its high miroestrol content, minus the side-effects caused by topical estrogen. Dr. Sandford Schwartz has researched PM for years, and his research, combined with the centuries of native Thai usage, has corroborated this claim. In fact, Dr. Sandford Schwartz has has sold his liquid PM extract formula to a well-known company in America to be distributed here for the purpose of hair regrowth. The formula consists exclusively of his liquid PM extract, by the name of Puresterol. Biobotanica is an independent U.S. distributor for Puresterol, and is our source of PM as well. You can read more about Puresterol at the following link:
Pueraria mirifica,Pueraria mirifica standardized extract, called Puresterol,research and studies,Puerariamirifica,pueraria, (http://www.puresterol.com)
Your trial bottle will either contain 0%, 2.5%, or 5% Pueraria Mirifica throughout the duration of this trial. We are not sure if PM will neutralize the other ingredients, if it will enhance it, or if it will make no discernible difference. The idea behind the variable amount is to test the optimal quantity for HairGen.
Adenosine
Adenosine is well-known around internet forums as a chemical that can increase the expression of Vascular Endothelial Growth Factor (VEGF), which has been found to be effective at thickening/terminalizing thin and vellous hairs. The amount of Adenosine in the formulation will be 3%. To view a study on the effectiveness of Adenosine, check out the following link:
Adenosine stimulates hair growth (http://news.hairlosshelp.com/hair-loss-studies/adenosine-stimulates-hair-growth/)
Sanguisorba Officinalis Extract
Sanguisorba Officinalis has an interesting method of action on the scalp that works in favor of preventing hair loss. Rather than reduce DHT, it inhibits Fibroblast Growth Factor-5 (FGF-5). FGF-5 is responsible for converting hairs from the Anagen (Growing) phase to the Telogen (Falling out) phase. By successfully inhibiting FGF-5, you can theoretically stop hair loss altogether. This, of course, does not apply to hairs currently in telogen phase prior to HairGen usage. You can view more information at the following link:
Science Links Japan | Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period (http://sciencelinks.jp/j-east/article/200704/000020070407A0130088.php)
Loquat Leaf Extract (Eriobotrya japonica)
The active component in Loquat Leaf Extract that yields promising results for hair loss is primarily Corosilic Acid. Corosilic Acid works in a similar manner to Sanguisorba Officinalis in that it regulates various growth factors when applied topically to the scalp. FGF-5 is downregulated (this works synergistically with Sanguisorba), while VEGF, FGF-7, and BMP-2, all of which are beneficial growth factors for hair loss, are upregulated. The following study offers further detailed information on the benefits of Loquat Leaf Extract and Corosilic Acid for hair loss:
Utilising loquat leaf extract for hair growth stimulation - Personal Care Magazine (http://www.personalcaremagazine.com/Story.aspx?Story=1911)
Semen Coicis Extract (Coix Seed or Coicis Lachryma-Jobi)
Though not as well-documented as some of the other ingredients in the formula, Coicis Semen has shown promise in the hair loss field as a Type II 5alpha-reductase inhibitor. The following study contains Coicis Semen as one of the primary ingredients in a hairloss formulation:
KMbase (http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0363620040250010152)
The next study refers to Thujae occidentalis semen, which is identical in action to Coicis Semen for our intents and purposes:
The extract of Thujae occidentalis semen inhibited...[J Dermatol Sci. 2003] - PubMed Result (http://www.ncbi.nlm.nih.gov/pubmed/12670719?dopt=AbstractPlus)
Swertia Chirata Extract
Swertia is effective as both an anti-inflammatory, and vasodilator. Topical application of Swertia can reduce shedding, while also encouraging thicker hair growth. Numerous hair loss formula patents have incorporated Swertia Chirata as a primary ingredient due to its Ayurvedic roots in hair loss treatment.
Red Panax Ginseng Extract
Red Panax Ginseng increases bloodflow and can stimulate hair follicles to encourage new hair growth. It has traditionally been used in Chinese medicine with success for thousands of years as a component in hair loss treatment. The following link has a large body of literature on uses for Red Panax Ginseng:
Panax ginseng C. A. Mey. (http://www.herbmed.org/Herbs/Herb108.htm)
Sophora Flavescens Extract
Hair loss studies point towards Sophora Flavescens as not only a potent inhibitor of Type II 5alpha-reductase, but also as an important regulator of growth factors.
The following study found that Insulin Growth Factor-1 (IGF-1) and Keratinocyte Growth Factor (KGF), both growth factors integral for hair growth, were up-regulated:
The hair growth promoting effect of Sophora flaves...[J Dermatol Sci. 2002] - PubMed Result (http://www.ncbi.nlm.nih.gov/pubmed/12354419?dopt=Abstract)
Toco-8
Toco-8 consists of the proper ratio of mixed Vitamin E tocotrienols that our bodies can make the best usage of. In a small study conducted by Primordial Performance, it was found that Toco-8 consumed internally can help in the fight against hair loss. Externally, it may be of even further benefit. Below is a link to a few live radio interviews with Primordial Performance President Eric Potratz regarding Toco-8 and the patented hair loss study:
http://www.primordialperformance.com/vbulletin/primordial-health/377-toco-8-balanced-tocotrienol-tocopherol-vitamin-e-supplement-radio-interview.html
Niacinamide
Topical Niacinamide has been shown to improve the condition of aged skin, helping to restore youthfulness and vitality. This may translate over to a healthier scalp that can improve the probability of thicker hair and potential regrowth. The following study demonstrates the effects of topical Niacinamide when applied to the face:
Wiley InterScience :: Session Cookies (http://www3.interscience.wiley.com/journal/118769826/abstract?CRETRY=1&SRETRY=0)
Niacin also acts as a vasodilator, which is similar in action to Minoxidil (sans the side-effects). A description of Niacin's vasodilation effects can be found here:
The role of niacin in detoxification (http://www.healingdaily.com/detoxification-diet/niacin.htm)
If you have any further questions, feel free to post them in this thread!